Attentional bias towards positive and negative imagery amongst offenders and non-offenders with intellectual disabilities

Introduction: Theories of moral reasoning, empathy and information processing have long been used to explain offending behaviour in people with intellectual disabilities (ID), and the way in which attention is allocated to stimuli is thought to be integral to developmental models of offending that incorporate these ideas (Garrigan & Langdon, In Press). The present study sought to examine empathy and attentional bias in ID offenders (IDO) and ID non-offenders (IDNO). Methods: Men with mild ID (IDO n = 34; IDNO n = 32) completed a self-report empathy measure, and an affective dot-probe task containing negative, positive, and neutral images. Reaction times (RT) to computerised trials were recorded. Results: (1) The IDO group had significantly lower empathy scores than the IDNO group; (2) within group comparisons showed that RT in the IDO group were similar across trial types, whilst the IDNO group had significantly slower RT the affective trials than neutral trials; (3) between group analysis revealed a significant group difference in attentional bias for negative-affective and global-affective stimuli (positive and negative images collapsed together); and (4) across all participants, attentional bias could not explain a significant percentage of the variance in empathy. Discussion: The findings suggest that IDO attentional allocation is unaffected by the stimuli content, whilst attention in the IDNO group is significantly biased away from negative- and global-affective information in comparison to IDO. However, attentional bias could not explain any variance in empathic abilities. The findings provide some support for the application of attentional theories of information processing to this population. Further research in people with ID could lead to the use of attentional bias paradigms as unbiased pre- and post-intervention measures, and may even have application in an intervention context, in the form of cognitive bias modification

Forecasting Truck Parking Using Fourier Transformations

Truck-based transportation is the predominant mode used to transport goods and raw materials within the United States. While trucks play a major role in local commerce, a significant portion of truck activity is also long haul in nature. Long-haul truck drivers are continuously faced with the problem of not being able to secure a safe parking spot since many rest areas become fully occupied, and information about parking and availability is limited. Truck drivers faced with full parking lots/facilities either continue driving until a safe parking spot is located or park illegally. Both scenarios pose a hazard to the truck driver, as well as the surrounding road users. Disseminating forecasts of parking availability to truck drivers may help mitigate this hazard, since many truck drivers plan their parking in advance of arrival. Building on 1 year of nearly continuous truck parking data collection, this paper proposes and demonstrates a method for developing a dynamic forecasting model that can predict truck parking occupancy for any specified time within the present day, using only truck parking occupancy data from a trucking logistics facility in the northern San Joaquin Valley during 2016. Different versions of the dynamic model were studied and verified against successive weekdays with performance measured using the root-mean-square error (RMSE). Results indicated that for a particular day, the maximum error can range between 13 and 40 trucks, about 5% of the absolute maximum capacity of the facility

Attentional bias toward negative and positive pictorial stimuli and its relationship with distorted cognitions, empathy, and moral reasoning among men with intellectual disabilities who have committed crimes

The aims of this study were to examine: (a) whether men with intellectual disabilities who have a history of criminal offending attend to affective pictorial stimuli in a biased manner, and (b) whether there is a relationship between an affective attentional bias and offence-supportive cognitions, empathy, and moral development. Forty-six men with intellectual disabilities who had a documented history of criminal offending, and 51 men who also had intellectual disabilities, but no such history, were recruited and asked to complete a computer-based dot-probe task using affective pictorial stimuli with randomisation, along with measures of distorted cognitions, empathy, and moral development. Those with a history of criminal offending endorsed significantly more offence-supportive cognitions, had significantly lower general empathy, and more “mature” moral development, as well as a significant attentional bias toward affective pictorial stimuli. Attentional bias significantly predicted offence-supportive cognitions, and vice versa, having controlled for offence history, and Full-Scale IQ, but this was not the case for empathy or moral development. While the findings require replication, interventions which aim to modify attention bias with this population should be tested

Apigenin and Structurally Related Flavonoids Allosterically Potentiate the Function of Human α7-Nicotinic Acetylcholine Receptors Expressed in SH-EP1 Cells

Phytochemicals, such as monoterpenes, polyphenols, curcuminoids, and flavonoids, are known to have anti-inflammatory, antioxidant, neuroprotective, and procognitive effects. In this study, the effects of several polyhydroxy flavonoids, as derivatives of differently substituted 5,7-dihydroxy-4H-chromen-4-one including apigenin, genistein, luteolin, kaempferol, quercetin, gossypetin, and phloretin with different lipophilicities (cLogP), as well as topological polar surface area (TPSA), were tested for induction of Ca2+ transients by α7 human nicotinic acetylcholine (α7 nACh) receptors expressed in SH-EP1 cells. Apigenin (10 μM) caused a significant potentiation of ACh (30 μM)-induced Ca2+ transients, but did not affect Ca2+ transients induced by high K+ (60 mM) containing solutions. Co-application of apigenin with ACh was equally effective as apigenin preincubation. However, the effect of apigenin significantly diminished by increasing ACh concentrations. The flavonoids tested also potentiated α7 nACh mediated Ca2+ transients with descending potency (highest to lowest) by genistein, gossypetin, kaempferol, luteolin, phloretin, quercetin, and apigenin. The specific binding of α7 nACh receptor antagonist [125I]-bungarotoxin remained unchanged in the presence of any of the tested polyhydroxy flavonoids, suggesting that these compounds act as positive allosteric modulators of the α7-nACh receptor in SH-EP1 cells. These findings suggest a clinical potential for these phytochemicals in the treatment of various human diseases from pain to inflammation and neural disease

Thujone inhibits the function of α7-nicotinic acetylcholine receptors and impairs nicotine-induced memory enhancement in one-trial passive avoidance paradigm

Effects of thujone, a major ingredient of absinthe, wormwood oil and some herbal medicines, were tested on the function of α7 subunit of the human nicotinic acetylcholine (α7 nACh) receptor expressed in Xenopus oocytes using the two-electrode voltage-clamp technique. Thujone reversibly inhibited ACh (100 μM)-induced currents with an IC50 value of 24.7 μM. The effect of thujone was not dependent on the membrane potential and did not involve Ca2+-dependent Cl- channels expressed endogenously in oocytes. Inhibition by thujone was not reversed by increasing ACh concentrations. Moreover, specific binding of [125I] -bungarotoxin was not altered by thujone. Further experiments in SH-EP1 cells expressing human α7 nACh receptor indicated that thujone suppressed choline induced Ca2+ transients in a concentration-dependent manner. In rat hippocampal CA3-dentate gyrus synapses, nicotine-induced enhancement of long-term potentiation was also inhibited by thujone. Furthermore, the results observed in in-vivo one-trial passive avoidance paradigm show that thujone (1.25 mg/kg, i.p.) significantly impaired nicotine-induced enhancement of learning and memory in Wistar rats. Collectively, our results indicate that thujone inhibits the function of the α7-nACh receptor and impairs cellular and behavioral correlates of cholinergic modulation of learning and memory

Inhibition of Human α7 Nicotinic Acetylcholine Receptors by Cyclic Monoterpene Carveol

Cyclic monoterpenes are a group of phytochemicals with antinociceptive, local anesthetic, and anti-inflammatory actions. Effects of cyclic monoterpenes including vanilin, pulegone, eugenole, carvone, carvacrol, carveol, thymol, thymoquinone, menthone, and limonene were investigated on the functional properties of the cloned α7 subunit of the human nicotinic acetylcholine receptor expressed in Xenopus oocytes. Monoterpenes inhibited the α7 nicotinic acetylcholine receptor in the order carveol\u3ethymoquinone\u3ecarvacrol\u3ementhone\u3ethymol\u3elimonene\u3eeugenole\u3epulegone≥carvone≥vanilin. Among the monoterpenes, carveol showed the highest potency on acetylcholine-induced responses, with IC50 of 8.3 µM. Carveol-induced inhibition was independent of the membrane potential and could not be reversed by increasing the concentration of acetylcholine. In line with functional experiments, docking studies indicated that cyclic monoterpenes such as carveol may interact with an allosteric site located in the α7 transmembrane domain. Our results indicate that cyclic monoterpenes inhibit the function of human α7 nicotinic acetylcholine receptors, with varying potencies

Menthol Binding and Inhibition of a7-Nicotinic Acetylcholine Receptors

Menthol is a common compound in pharmaceutical and commercial products and a popular additive to cigarettes. The molecular targets of menthol remain poorly defined. In this study we show an effect of menthol on the α7 subunit of the nicotinic acetylcholine (nACh) receptor function. Using a two-electrode voltage-clamp technique, menthol was found to reversibly inhibit α7-nACh receptors heterologously expressed in Xenopus oocytes. Inhibition by menthol was not dependent on the membrane potential and did not involve endogenous Ca2+-dependent Cl− channels, since menthol inhibition remained unchanged by intracellular injection of the Ca2+ chelator BAPTA and perfusion with Ca2+-free bathing solution containing Ba2+. Furthermore, increasing ACh concentrations did not reverse menthol inhibition and the specific binding of [125I] α-bungarotoxin was not attenuated by menthol. Studies of α7- nACh receptors endogenously expressed in neural cells demonstrate that menthol attenuates α7 mediated Ca2+ transients in the cell body and neurite. In conclusion, our results suggest that menthol inhibits α7-nACh receptors in a noncompetitive manner

Cognitive-behavioural therapy for anxiety in dementia: pilot randomised controlled trial

Background Anxiety is common and problematic in dementia, yet there is a lack of effective treatments. Aims To develop a cognitive–behavioural therapy (CBT) manual for anxiety in dementia and determine its feasibility through a randomised controlled trial. Method A ten-session CBT manual was developed. Participants with dementia and anxiety (and their carers) were randomly allocated to CBT plus treatment as usual (TAU) (n = 25) or TAU (n = 25). Outcome and cost measures were administered at baseline, 15 weeks and 6 months. Results At 15 weeks, there was an adjusted difference in anxiety (using the Rating Anxiety in Dementia scale) of (–3.10, 95% CI –6.55 to 0.34) for CBT compared with TAU, which just fell short of statistical significance. There were significant improvements in depression at 15 weeks after adjustment (–5.37, 95% CI –9.50 to –1.25). Improvements remained significant at 6 months. CBT was cost neutral. Conclusions CBT was feasible (in terms of recruitment, acceptability and attrition) and effective. A fully powered RCT is now required

A behavioral comparison of male and female adults with high functioning autism spectrum conditions

Autism spectrum conditions (ASC) affect more males than females in the general population. However, within ASC it is unclear if there are phenotypic sex differences. Testing for similarities and differences between the sexes is important not only for clinical assessment but also has implications for theories of typical sex differences and of autism. Using cognitive and behavioral measures, we investigated similarities and differences between the sexes in age- and IQ-matched adults with ASC (high-functioning autism or Asperger syndrome). Of the 83 (45 males and 38 females) participants, 62 (33 males and 29 females) met Autism Diagnostic Interview-Revised (ADI-R) cut-off criteria for autism in childhood and were included in all subsequent analyses. The severity of childhood core autism symptoms did not differ between the sexes. Males and females also did not differ in self-reported empathy, systemizing, anxiety, depression, and obsessive-compulsive traits/symptoms or mentalizing performance. However, adult females with ASC showed more lifetime sensory symptoms (p = 0.036), fewer current socio-communication difficulties (p = 0.001), and more self-reported autistic traits (p = 0.012) than males. In addition, females with ASC who also had developmental language delay had lower current performance IQ than those without developmental language delay (p<0.001), a pattern not seen in males. The absence of typical sex differences in empathizing-systemizing profiles within the autism spectrum confirms a prediction from the extreme male brain theory. Behavioral sex differences within ASC may also reflect different developmental mechanisms between males and females with ASC. We discuss the importance of the superficially better socio-communication ability in adult females with ASC in terms of why females with ASC may more often go under-recognized, and receive their diagnosis later, than males